Monday, 24 Jun 2019

Fibromyalgia/Pain

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30 May 2019 Social 184 juvenile Fibromyalga pts randomized to PBO or duloxetine (30-->60mg/d) for 13wks. Those on duloxetine failed the primary endpoint - mean 24 hr change in Brief Pain Inventory (BPI), but more Cymbalt pts had 30% nd 50% BPI reductions https://t.co/EuyCRqKzN7
28 May 2019 Social Lyrica is FDA approved for FM, Neuopathy & adjunctive Rx for partial-onset seizures; but recently failed to meet primary endpoint in a phase III RCT to prevent primary gen tonic-clonic seizures.- but is continuing to develop it for pediatric epilepsy. https://t.co/T9T0Kv1wkP
14 May 2019 Social overall prevalence of low back pain among US workers is 26.4%, with 5.6% having severe LBP, according to May 14th Annals of Internal Medicine. https://t.co/5sfYFQWHyh
09 May 2019 News Gabapentinoid Drugs Overuse and Misuse
09 May 2019 Social 23 pts with Fibromyalgia were compared to non-diabetic Framingham and NHANES cohorts and shown to have significantly higher Hgb-A1c levels; suggesting insulin resistence in FM. 16 pts were given metformin and 50% had complete pain resolution (=0) https://t.co/OsbGFhcaCd
07 May 2019 News Pilot Study Targets Insulin Resistence in Fibromyalgia
22 Apr 2019 News Sleep Myths Debunked
01 Apr 2019 News RheumNowLive On Demand: The History of Fibromyalgia - Dr. Fred Wolfe
20 Mar 2019 Social Pain signaling via NMDA receptors in the brain can be treated with drugs that block NMDA receptors (ketamine, methadone, memantine, amantadine, dextromethorphan). Metanalysis of memantine (15 studies) shows little benefit. https://t.co/72yfYzDXhV
19 Mar 2019 Social Brain fog (Fibro Fog) is common with sleep disorders and fibromyalgia. Manifests as memory problems, poor mental focus, forgetfulness - all correctable with sleep medicine evaluation and sleep assistance. https://t.co/e6CXXkYV39
14 Mar 2019 Social Study from American Academy of Orthopaedic Surgeons' annual meeting in Las Vegas shows that 1 in 3 US kids (ages 10 -18 yrs) have back pain - from a survey of 3,700 kids. Risk increases w/ age, weight, playing competitive sports. https://t.co/p0KyXQVPYU
11 Mar 2019 News New Sleep Medicine Guidelines for Obstructive Sleep Apnea
11 Mar 2019 Social CORRONA Registry - Chronic opioid use doubled 2002-2015, rising from 7.4% to 16.9%. Strongest predictors included severe pain (HR 2.53), antidepressant use (HR 1.79), high Dz activity (HR 1.55) & high disability (HR 1.45). https://t.co/vPBqvWIy19
07 Mar 2019 Social A study of 2,369 patients with fibromyalgia showed the mean time from initial complaint to diagnosis was 6.42 years. Comorbidity, younger patient, and older physician age were associated with longer time to diagnosis. https://t.co/mHGIR7C4PW
25 Feb 2019 Social Among 548 pts referred to academic pain center & treated for back pain, 42% met fibromyalgia criteria. FM+ pts were more likely to be younger, unemployed, w/ greater pain severity, more neuropathic pain, depression, anxiety & lower physical function https://t.co/gse5CDnJ13
07 Feb 2019 Social Study of 497 rheumatology clinic pts shows 24% met fibromyalgia criteria, while 21% had a ICD-10 Dx of FM. Clinicians and criteria agreement was only fair (κ = 0.41). MD failed to Dx identify 60 criteria (+) pts & wrongly dx 43 criteria‐negative pts https://t.co/sZobOovOW4
05 Feb 2019 News Pain Drives the Use of Medical Marijuana
05 Feb 2019 News Compounded Pain Creams - Expensive Placebos?
07 Jan 2019 News Opioids Double Rates of Suicides and Overdoses
28 Dec 2018 Social To order ANA test in FM or "pain AllOver" pts is wrong; to order more subserologies(dsDNA,RNP,Sm) should be criminal https://t.co/FMkOsiQrXr