Wednesday, 20 Nov 2019

Drug Safety

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18 Jul 2019 Social anti-MDA5+ amyopathic dermatomyositis (ADM) with ILD is severe and refractory. NEJM letter reports on 18 ADM Rx w/ tofacitinibs who showed better 6 mo survival (100% vs 78%) (P=0.04) and improved ferritin, FVC, DLCO, & CT Chest over time.
18 Jul 2019 Social Can Febuxostat be given to Allopurinol Hypersensitivity? Such pts not included in registrations trials; yet many literature reports of no toxicity & rare cross-Rxn; PI says ULORIC indicated w/ intolerant to allopurinol, or when allopurinol Tx not advisable
10 Jul 2019 News EHR-Related Adverse Events Usually Involve Medications
10 Jul 2019 Social CBD isn't entirely safe. Forbes reviews evidence of hepatotoxicity, esp with the CBD-based epilepsy drug Epidiolex; in studies 5-20% had liver issues. FDA has also warned of suicidal ideation, agitation, suicide, depression, aggression & panic attacks
09 Jul 2019 Social Metanalysis of 277 RCTs &1 million evaluated 16 nutritional supplements & 8 dietary interventions showed largely no effect on mortality and CV outcomes in adults. There was evidence favoring reduced salt & omega-3, long-chain fatty acids.
09 Jul 2019 Social RTX product label list these postmarketing AEs (not seen in trials) - uveitis, optic neuritis, systemic vasculitis, pleuritis, lupus-like syndrome, serum sickness, polyarticular arthritis, and vasculitis with rash.
05 Jul 2019 Social RT @RheumNow: Dr. Kevin Winthrop - Expert Advice on TB Testing and Treatment from #EULAR2019
28 Jun 2019 Social RheumNow Podcast is UP! Discussions of MTX stomatitis, Loading doses, PPD Shortage, infection risk from steroids or THR/TKR and more. Watch it here>> or listen in on iTunes or SoundCloud >>
27 Jun 2019 Social Metanalysis of 3954 studies, 20 RCTs examined MTX toxicity and found the prevalence of alopecia to be 1- 4.9% and the prevalence of stomatitis to be between 5.7-8%
26 Jun 2019 Social ORAL Strategy, 216 or 18.8% received the Zostvax vaccine. Overall, 18 patients (1.6%) developed HZ (vaccinated=3; non-vaccinated=15). HZ IRs (95% CI) were 1.1 (0.3, 2.9), 2.3 (1.0, 4.6), and 1.7 (0.6, 3.7) for tofa monotherapy, tofa+MTX, & ADA+MTX, resp.
20 Jun 2019 Social Methotrexate assoc. lymphoproliferative disorders (LPDs), is a rare disorder that resolves w/ MTX withdrawal (in 3-10mos). Most common path was diffuse large B-cell lymphoma and 45-77% had Epstein-Barr virus encoded RNA positivity.
19 Jun 2019 ACR Video RNL Preview with Dr. Lisa Sammaritano: Anti-Rheumatic Drug Use with Pregnancy
17 Jun 2019 Social RT @tuna0sashimi: MTX withdrawal in tofacitinib MR 11mg ORAL shift 1y study @week 24, MTX blindly withdrawal for pt achieved LDA (CDAI <=10…
17 Jun 2019 Social RT @tuna0sashimi: Please please publish this so we can quote it for our patients RT @CreakyJoints: Reassuring news about hair loss and meth…
06 Jun 2019 Social FDA sent an "untitled"letter to "R3 Stem Cell" for touting birth tissue products as Rx for ailments (without scientific evidence). FDA also won a case against "US Stem Cell clinics" for adulterated & misbranded stem cell products
06 Jun 2019 Social Transparency is coming? The Prices will soon be Included in TV Drug Ads. HHS Secretary Alex Azar has finalized regulations requiring drug companies to disclose list prices of medications costing more than $35 for a month’s supply.
05 Jun 2019 Social CDC has updated its recommendations for TB testing of health care personnel. All HCP should be tested initially but after TB risk assessment, there is no need for routine or serial TB testing in the absence of exposure or ongoing risk of TB.
04 Jun 2019 Slide of the day FDA Reviews Febuxostat CV Safety
02 Jun 2019 Social RheumNow Podcast is up! What to monitor with RTX therapy. Watch here> or listen to the podcast on iTunes or SoundCloud>>
29 May 2019 Social FDA is seeking public input into CBD - cannabidiol - and will be holding a public hearing on CBD this friday May 31st.