Wednesday, 19 Feb 2020

Drug Safety

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17 Feb 2020 Social FDA has approved OTC voltaren (diclofenac) gel, now called Voltaren Arthritis Pain for arthritis & OA pain; it is not for immediate relief and may take up to 7 days to work. Pts should seek medical attention If they need to use this product for >21 days.
15 Feb 2020 Social RT @uptoTate: Dr. Postolova recommends checking immunoglobulins and flow cytometry on every patient prior to starting RTX. #RWCS2020 @Rheum…
15 Feb 2020 Social RT @uptoTate: Fewer VTE and HZ in filgotinib trials. More studies needed for proof of efficacy. Drs. Fleischmann and Genovese. #RWCS2020 @R…
15 Feb 2020 Social A favorable safety profile for Filgotinib, maybe less zoster and VTE. Drs. Fleischman/Genovese at #RWCS2020 @RWCSmtg
13 Feb 2020 Social RT @Janetbirdope: Different classification of allergic Rxns. Dr Anna Postolova #RWCS2020 @RheumNow
13 Feb 2020 Social Cutaneous side effects with steroids. Striae are irreversible!! Dr. George Martin #RWCS2020 @RWCSmtg
12 Feb 2020 Social Despite the AAOS recommendation to wait 5 yesterday for plaquenil eye screening, many rheums still do annual eye exams on HCQ, including Dr AWells #RWCS @RWCSmtg
12 Feb 2020 Social Teprotumumab effective in thyroid associated ophthalmopsthy it inhibits IGF 1 Dr AWells #RWCS @RWCSmtg
12 Feb 2020 Social Ocular toxicities with immune checkpoint inhibitors from Dr AWells #RWCS @RWCSmtg
12 Feb 2020 News Overmedication of America
11 Feb 2020 Social After all these years.... the specific MOA by which glucocorticoids mediate anti-inflammatory effects is still unclear. Full read review in Nature Rheumatology. Many effect thought to be mediated thru glucocorticoid receptor functioning
10 Feb 2020 Social Open label study of Abatacept in 79 patients with primary Sjogrens syndrome showed no difference between those treated wtih ABA vs Placebo.
08 Feb 2020 Social RT @NEJM: Placebo and nocebo effects are powerful and pervasive in clinical practice. Neurobiologic mechanisms, information offered about t…
05 Feb 2020 Social Claims cohort study looked at serious infection in RA pts Rx w/ tofacitinib vs 7 biologics. Overall risk was 3.12/100PYs. Signif higher SIE in TOFA vs ETN (aHR 1·41), lower vs INFLX (0.81), similar to ABA, GOL, TCZ, ADA. TOFA 2X higher risk of Shingles
28 Jan 2020 Social Study of 260 TB patients treated with pyrazinamide or fluoroquinolones showed a higher risk of joint pain (mostly ankles knees) with FQN (29%) vs PZA (17%); median latency was 55 days vs 138 days; half had hyperuricemia.
28 Jan 2020 Social ENTRACTE trial studied the risk of major adverse CV events (MACE) in 3080 RA pts Rx with tocilizumab (TCZ) vs etanercept (ETN), and found no increased risk of MACE in TCZ patients compared to ETN (HR 1.05 (95% condence interval 0.77–1.43).
21 Jan 2020 Social Hydroxychloroquine in RA metanalysis shows clinical efficacy of HCQ was similar to or lower than MTX or SSZ monotherapy. When HCQ combined with other DMARDs it increased the clinical efficacy. There is a paucity of data on HCQ structural (Xray) benefits
19 Jan 2020 Social RT @RheumNow: RheumNow Podcast is up! S ame day hip replacments? Steroids & organ damage; Watch it here>> or list…
19 Jan 2020 Social RT @EBRheum: TAKT RCT of TCZ vs PLBO in takayasu arteritis, 96wk open label extension just published PMID 31951279 Good GC taper/sparing,…
19 Jan 2020 Social RT @psufka: This article by Artie Kavanaugh from @RheumNow got me thinking about whether there is any data for using pulse dose (500-1000mg…