Tuesday, 12 Nov 2019

Bone/OP&OA

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29 Aug 2019 News High-Dose Vitamin D: No Help for Bone Health
26 Aug 2019 Social Metanalysis of 57 articles describing 154 prognostic factors for Hip OA progression. 4 were assoc w/ increased risk = comorbidity, higher KL, superior head migration, subchondral sclerosis. Not predictive=gender, pain meds, QOL, limited ROM. https://t.co/bIa1Z0dimG
22 Aug 2019 Social RCT of 139 knee OA pts given either curcumin 500-mg tid or diclofenac 50-mg bid. At days 14 and 28 both had similar improvement in pain and KOOS score; but curcumin had better tolerance, less GI sxs and H2 blocker use. https://t.co/tcsDQWQOMg
22 Aug 2019 Social Retrospective review of US-guided Synovial Biopsies performed (clinical practice n=52, research n=12) - syn tissue obtained in 88%. Utility/impact was good (37% Dx impact, >95% PPV or NPV for infection & research 92% success. https://t.co/A7vzIHnKH1
21 Aug 2019 News Osteoporosis Tx: Good for Bones, but Not for Cutting Death Risk
13 Aug 2019 News Bisphosphonate Use Associated with Reduced Mortality
13 Aug 2019 Social Osteoarthritis Iniative study of 3053 #OA pts shows worsening in health related quality of life is most rapid with Female gender, higher BMI, smoking, knee pain, and lower income at baseline. Rapid progressors had higher risk of TKR (HR 6.2;CI 3.6–10.7) https://t.co/73OlM7ymH6
12 Aug 2019 Social Nearly 30% of presurgical OA (Spine> Hip &Knee) used prescription opioids. Opioid use was greater w/ spine OA (vs knee), obesity, smokers, depression, greater pain, higher TJC, & concurrent use of other pain meds https://t.co/ns6JBB7BXU
11 Aug 2019 Social Osteoarthritis Iniative study of 3053 #OA pts shows worsening in health related quality of life is most rapid with Female gender, higher BMI, smoking, knee pain, and lower income at baseline. Rapid progressors had higher risk of TKR (HR 6.2;CI 3.6–10.7) https://t.co/73OlM7ymH6
05 Aug 2019 Social The RheumNow Podcast is up – More on osteoporosis, myositis, lipids and gout, testosterone, abatacept in PSS & Boxed Warning for tofacitinib. Watch it here>> https://t.co/I1lBS1lUmY or listen to the Podcast on iTunes or SoundCloud here>> https://t.co/uYyPV7pxcN
04 Aug 2019 Social My advice to Patients on Joint Replacement Surgey: 1) talk to others who had the surgery; 2) consult orthopedics LONG before its urgent; 3) PRE-hab (getting strong before surgery); 4) Get a physical therapist who will work you to normal (3-5X/wk for 4-8 wks)
01 Aug 2019 Social Phase IIb/III trial of multidoses of fasinumab (NGF mAb) in 421 pts w/ mod‐severe hip or knee #OA (WOMAC pain ~6+) showed signif reductions in pain (LMS -1.1 to -1.4) vs PBO (-.79) & >30% improved pain by @wk16 (63–74 vs 47%); arthropathy 7% FAS vs 1%PBO https://t.co/UtkqDE5lGf
30 Jul 2019 Social Is tea consumption associated with a risk of fractures? A metanalysis of 16 studies, 772,707 participants, high (compared to low) tea consumption was associated a lower fracture risk - RR 0.86 (0.78–0.94). https://t.co/24XYyUArS9
22 Jul 2019 News Partial or Total Knee Replacement for Osteoarthritis?
18 Jul 2019 News Intraarticular Capsaicin in Knee Osteoarthritis
18 Jul 2019 News Increased Risk of Cardiovascular Death in Hip and Knee Osteoarthritis
16 Jul 2019 Social Analysis #osteoarthritis clinical trials placebo response ratio (PRR) as the placebo to treatment effect size ratio. PRR was best for walking time/distance (0.30, 95% CI 0.16 to 0.43) and worst for PRO pain (0.44, 95% CI 0.23 to 0.65) https://t.co/4VorQdSIV2
10 Jul 2019 News Safety Concerns Offset the Modest Improvements of Tanezumab in Osteoarthritis
08 Jul 2019 News Benefits vs Harms for Osteoporosis Drug Continuation or Discontinuation
27 Jun 2019 News Mortality from Falls in the Elderly